The GLS’ pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Pilot doesn’t offer pre-crash pretensioners.
The GLS offers an optional Post Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Pilot doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the GLS. But it costs extra on the Pilot.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Pilot doesn’t offer a system that can receive automated systems from other vehicles.
The GLS has a standard blind spot warning system that uses sensors to alert the driver to objects in the vehicle’s blind spots where the side view mirrors don’t reveal them and moves the vehicle back into its lane. Only the Pilot Sport/EX-L/TrailSport/Touring/Elite offers a blind spot warning system.
To help make backing out of a parking space safer, the GLS has standard Rear Cross-Traffic Alert and Active Brake Assist automatically engages the brakes to help avoid a collision. Only the Pilot Sport/EX-L/TrailSport/Touring/Elite offers Cross Traffic Monitor and the Pilot’s Cross Traffic Monitor does not include automatic braking.
Both the GLS and the Pilot have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, rearview cameras and driver alert monitors.
The Mercedes GLS weighs 804 to 2190 pounds more than the Honda Pilot. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

