The GLS offers an optional Post Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The GX doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The GX doesn’t offer a system that can receive automated systems from other vehicles.
Both the GLS and GX have Rear Cross-Traffic Alert, but the GLS has Active Brake Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The GX’s Rear Cross-Traffic Alert doesn’t automatically brake.
For better protection of the passenger compartment, the GLS uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The GX uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the GLS and the GX have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.

