The AMG E-Class Sedan has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The Panamera doesn’t offer front seat center airbags.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the AMG E-Class Sedan. But it costs extra on the Panamera.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The AMG E-Class Sedan has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Panamera doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the AMG E-Class Sedan and the Panamera have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available lane departure warning systems.

