The AMG S-Class has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The Panamera doesn’t offer front seat center airbags.
The rear seatbelts optional on the AMG S-Class inflate when a collision is detected, helping to spread crash forces over a much larger area of the body and limiting head and neck movement. This can help prevent spinal and internal injuries. The Panamera doesn’t offer inflatable seatbelts.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the AMG S-Class. But it costs extra on the Panamera.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The AMG S-Class has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Panamera doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the AMG S-Class and the Panamera have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
The Mercedes AMG S-Class weighs 409 to 1425 pounds more than the Porsche Panamera. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.